Circulating and disseminated tumor cells: harbingers or initiators of metastasis?
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چکیده
منابع مشابه
Circulating and disseminated tumor cells: harbingers or initiators of metastasis?
Tumor cells leave the primary tumor and enter the circulation. Once there, they are called circulating tumor cells (CTCs). A fraction of CTCs are capable of entering distant sites and persisting as disseminated tumor cells (DTCs). An even smaller fraction of DTCs are capable of progressing toward metastases. It is known that the DTC microenvironment plays an important role in sustaining their s...
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Cancer is a prominent cause of death worldwide. In most cases, it is not the primary tumor which causes death, but the metastases. Metastatic tumors are spread over the entire human body and are more difficult to remove or treat than the primary tumor. In a patient with metastatic disease, circulating tumor cells (CTCs) can be found in venous blood. These circulating tumor cells are part of the...
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Circulating tumor cells (CTCs) were added to the arsenal of clinical testing in 2004 for three cancer types: metastatic breast, prostate, and colorectal cancer. CTCs were found to be an independent prognostic indicator of survival for these three diseases. Multiple enrichment/isolation strategies have been developed and numerous assay applications have been performed using both single and poole...
متن کاملDisseminated and Circulating Tumor Cells in Gastrointestinal Oncology
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متن کاملDisseminated and circulating tumor cells in gastrointestinal oncology.
Circulating (CTCs) and disseminated tumor cells (DTCs) are two different steps in the metastatic process. Several recent techniques have allowed detection of these cells in patients, and have generated many results using different isolation techniques in small cohorts. Herein, we review the detection results and their clinical consequence in esophageal, gastric, pancreatic, colorectal, and live...
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ژورنال
عنوان ژورنال: Molecular Oncology
سال: 2017
ISSN: 1574-7891,1878-0261
DOI: 10.1002/1878-0261.12022